Hematopoietic stem cells are able to maintain a lifelong supply of the entire spectrum of blood cells, dependent on the varying systemic demands of the individual. However, with the development of new technologies such as omics approaches at singlecell resolution, recent studies in vitro and in vivo have suggested that heterogeneity is a common. Hematopoiesis definition of hematopoiesis by medical dictionary. As the animal grows, hematopoietic activity in the central areas of long bones regresses and is. Carotid 18 ffdg uptake was increased in patients compared with. During embryonic development, this function is performed mainly in the spleen, liver and bone marrow, and after the birth the production of these elements is performed mainly by. Global glossary on donation and transplantation final version. In the embryo and fetus it takes place in a variety of sites including the liver, spleen, thymus, lymph nodes, and bone. Ppt hematology hematopoiesis powerpoint presentation.
The hematopoietic system is formed by bodies responsible for haematopoiesis, or the production of the cellular elements of blood. Overview hematopoiesis development from stem cell definitions type identification of. The relationship between endothelial cells ec and haematopoietic cells hc has been seen as an indication that a common progenitor, the haemangioblast, gives rise to both cell types in the yolk. All differentiated blood cells from the lymphoid and myeloid lineages arise from hscs. The 2008 world health organization who classification of hematopoietic and lymphoid tumors and the associated monograph represent the established guidelines for the diagnosis of malignant lymphomas. There is conservation of the overall hematopoietic process. Leukopenia and transplantation joseph yossi schwartz, md director, hemotherapy and stem cell processing facility email. Here we present a crisprcas9 geneediting system that combines cas9 ribonucleoproteins and adenoassociated viral vector delivery of a homologous donor to achieve homologous recombination at. The current revision, known as the 4th revised edition, was. Definition hematopoiesis is the proliferation of progenitor cells, which are maintained by the stem cells and their differentiation into all the cellular components of blood. Hematopoietic stem cells, stem cell processing, and. Medullary stage by the 5th month blood cell formation occurs in the bone marrow. Microsoft powerpoint hematopoietic lecture ppt author.
Childhood hematopoietic cell transplantation involves the infusion of blood stem cells into a patient to reconstitute the blood system. It is anticipated that the glossary will be completed and adapted with the progress of global consensus. When you save presentation as a pdf file it freezes the formatting and layout. Hematopoietic stem cells an overview sciencedirect topics. Low initial bmi and more pronounced weight loss during hct are strong prognostic indicators associated with lower survival and worse disease outcomes n156 aml pts.
Extramedullary hematopoiesis is the formation of blood cells at sites other than the bone marrow. Leukopenia haematopoietic and lymphoid tissues, iarc press, lyon 2001. Jan 11, 2010 the haematopoietic system is one of the first major organs to form, initially to supply the growing embryo with oxygen and later also to permit remodelling of tissue anlagen into the adult form moore, 2004. Background to the haematopoietic stem cell transplant hsct procedure. Time line 12 4 2 0 1 2 6 60 month marrow s failure disease remission disease recurrenc e continuous complete remission cure highdose therapy primary diagnosis and treatment relapse and salvage therapy disease state. Hematopoietic system definition of hematopoietic system. Hematopoietic stem cells hscs are multipotent, selfrenewing progenitor cells that develop from mesodermal hemangioblast cells. Hematopoiesis is a complex process that begins with an uncommitted pluripotent hematopoietic stem cell that progresses through a series of steps to development of a singlelineage progenitor cell. Worlds best powerpoint templates crystalgraphics offers more powerpoint templates than anyone else in the world, with over 4 million to choose from. Haematopoiesis normally occurs in the flat bones, such as the pelvis, breastbone and shoulderblades, but in times of extra demand may extend to other bones or even other tissues such as the liver. Haemopoiesis haemopoiesis is from greek meaning to make new blood it refers to the formation of blood cellular components all blood cellular components are derived from a haematopoietic stem cells in a healthy adult approx 1011 1012 new blood cells are produced daily. Haematopoietic stem cell transplantation linkedin slideshare.
A revised europeanamerican classification of lymphoid neoplasms. In the embryo and fetus it takes place in a variety of sites including the liver, spleen, thymus, lymph nodes, and bone marrow. Scribd is the worlds largest social reading and publishing site. Choose from 142 different sets of haematopoietic flashcards on quizlet. Diseases characterized by haematopoietic insufficiency, such as aplastic anaemia, should therefore be investigated for abnormal expression of these regulatory proteins. The world health organization who classification of tumors of hematopoietic and lymphoid tissues is the most widely used pathologic classification system for hematolymphoid neoplasms. Rbcs, wbcs and platelets is called as haematopoiesis and the sites where it occurs are known as hemopoietic tissues or organs bone marrow, liver, spleen cells responsible to do function of hemopoiesis are first seen in yolk sac of embryo in third week of embryonic development and these. Initially red marrow replaces yellow marrow fat at metaphyses and along endosteal surface of diaphysis. Hematopoiesis the process by which blood cells are formed has been studied intensely for over a century using a variety of model systems.
Our new crystalgraphics chart and diagram slides for powerpoint is a collection of over impressively designed datadriven chart and editable diagram s guaranteed to impress any audience. Hematopoiesis definition of hematopoiesis by medical. Hscs can be found in adult bone marrow, peripheral blood, and umbilical cord blood. The identification of adult bone marrow as a source of haematopoietic cells capable of protecting. Myeloid leukemia undergoing haematopoietic stem cell transplantation. The formation and development of blood cells is a very complex process, called hematopoiesis. Called also hematogenesis, hemogenesis, and hemopoiesis. A hematopoietic stem cell is a cell isolated from the blood or bone marrow that can renew itself, can differentiate to a variety of specialized cells, can mobilize out of the bone marrow into circulating. The role of cytokines in haematopoiesis schwarzmeier 1996. Rbcs, wbcs and platelets is called as haematopoiesis and the sites. Save powerpoint presentations as pdf files office support. Ppt hematopoietic stem cells powerpoint presentation free. Winner of the standing ovation award for best powerpoint templates from presentations magazine. Get detailed information about autologous and allogeneic transplant.
There is conservation of the overall hematopoietic process between vertebrates, although some differences do exist. Who classification of tumors of hematopoietic and lymphoid. In studies on hairy cell leukaemia, a severe deficiency was found in the production of interleukin. Haematopoietic stem cell mobilisation and apheresis. Haematopoietic stem cell transplantation hsct for ads over the last 20 years, hsct has also been used to treat severe ads, as it is an effective means by which to suppress the abnormal in. Compared to patients with a baseline bmi kgm2 of 2025, a low bmi. People can view the slides even if they dont have powerpoint, but they cant make changes to it. Users are invited to refer to the whotransplantation website and to indicate the date of consultation if they quote the glossary. Graftversushost disease gvhd remains one of the major causes of morbidity and mortality that limit the success of haematopoietic cell transplantation hct. Studying hematopoiesis can help scientists and clinicians to understand better the processes behind blood disorders and cancers. Over the last decade, the zebrafish has come to the forefront as a new model in hematopoiesis research, as it allows the use of large. And while extramedullary hematopoiesis is the norm for a baby in the womb, once a person is born, it is generally a sign of disease or an indication that the bone marrow is unable to produce enough healthy red blood cells to meet the demand. The 2008 world health organization who classification of hematopoietic and lymphoid tumors and the associated monograph represent the established guidelines for the diagnosis of malignant.
Niche cells green underlying a basement membrane signal to stem cells red to block differentiation and regulate division. Mesoblastic stage first month of embryonic life where cells are formed outside the embryo in the mesenchyme of the yolk sac hepatic stage by the 6th week. Ppt hematopoietic stem cells powerpoint presentation. Haematopoietic definition of haematopoietic by the free.
General information for patients and carers considering. Monophyletic theory all blood cells come from one origin stem cell the. The classical roadmap of hematopoietic hierarchy has been proposed for nearly 20 years and has become a dogma of stem cell research for most types of adult stem cells, including hematopoietic stem cells hscs. Molecular monitoring of adenovirus reactivation in faeces after haematopoietic stemcell transplantation to predict systemic infection. Haematopoiesis definition of haematopoiesis by medical.
This process involves a small population of cells called hematopoietic stem cells hscs. Part 2 haematopoietic stem cell transplantation chapter 07. For patients with metastatic responding breast cancer or medulloblastoma, autologous haematopoietic stem cell transplantation can be considered when the benefits outweigh the risks, although additional studies are warranted. The 2016 revision of the world health organization. A canonical to noncanonical wnt signalling switch in haematopoietic stemcell ageing. Theyll give your presentations a professional, memorable appearance the kind of sophisticated look that todays audiences expect. Throughout ontogeny, the haematopoietic system has a high turnover requiring constant production of new cells. Hepatic stage by the 6th week medullary stage by the 5th month blood cell formation occurs in the bone marrow. The hscs are undifferentiated cells, located in the bone marrow before they become mature blood cells and enter the blood stream. In the publish as pdf or xps dialog box, choose a location to save the file to. Figure 1ac illustrates the multiple levels at which 18 ffdg uptake was assessed in both patients and matched controls. Jun 15, 20 hematopoiesis the formation of blood cellular components occurs during embryonic development and throughout adulthood to produce and replenish the blood system. Molecular monitoring of adenovirus reactivation in faeces.